SAT-LB89 Choriocarcinoma Induced Hyperthyroidism: Molecular Mimicry Between HCG and TSH

hCG Induced Hyperthyroidism Due to a Metastatic Germ Cell Tumor

Molecular mimicry between spermatozoa and bacteria.

PURPOSE Sperm immobilization factor isolated from Staphylococcus aureus immobilizes human spermatozoa as well as motile bacteria, showing that sperm immobilization factor receptor might be shared by bacteria and human spermatozoa. Thus, we sought to identify a common sperm immobilization factor binding receptor on spermatozoa and bacteria. MATERIALS AND METHODS Sperm immobilization factor was...

Choriocarcinoma-like human chorionic gonadotrophin (HCG) and HCG bioactivity during the first trimester of pregnancy.

The objective of this study was to evaluate the distribution of choriocarcinoma-like human chorionic gonadotrophin (HCG) isoforms during first trimester pregnancy and their relationship with in-vitro HCG bioactivity. This was done by means of a retrospective analysis of patients' sera with first trimester normal intrauterine and abnormal (ectopic) pregnancies. Serum samples were obtained from 3...

Radioimmunoassay of thyroid related hormones and TSH in primary hyperthyroidism.

One hundred and forty seven clinically proven hyperthyroid subjects were studied using radioimmunoassay techniques for the estimation of serum thyroid hormones and pituitaryTSH concentrations. In females toxic goitre was more frequently seen in the age group 21 to 30 years and in males 31 to 40 years. The mean levels for serum T4, T3, FT4 and FT1 were significantly elevated while the mean level...

TSH receptor gene mutations and familial gestational hyperthyroidism.

‘Gestational hyperthyroidism’ is a clinical condition characterized by thyrotoxicosis and hyperemesis gravidarum and generally occurs in 1–2% of all normal pregnancies. It represents an extreme degree of morning nausea and vomiting in early pregnancy, accompanied by weight loss, ketonemia, acetonuria, and profound volume depletion. Within the last decade, the association of abnormal thyroid fun...